News & Events
June 2018 PAPER
Analysis of over 1 million individuals revealed that psychiatric and neurological disorders are relatively genetically distinct from one another. Published in Science, this analysis also supports previous findings of shared genetic effects across psychiatric disorders like schizophrenia, depression, bipolar disorder, and PTSD. Popular media coverage is available: Scientific American, The Economist
May 2018 CONFERENCES
May was a month for meetings, with Dr. Duncan presenting at the Society of Biological Psychiatry in NYC, participating in the Pathways to Drugs Meeting in Copenhagen, and hosting a regional symposium at Stanford on Cross Population Genetics, supported by Population Health Sciences (PHS) and the Center for Computational Evolutionary and Human Genetics (CEHG). Thanks to all involved for fantastic collaborations.
Genetic Correlation Profile of Schizophrenia
Duncan et al (2018 in press) Schizophrenia Bulletin
Using genetic correlation analyses we find genetic relationships between schizophrenia and personality traits (openness to experience and neuroticism). We also find evidence for a novel risk pathway that includes citrate, and this mechanism may link “common” polygenic forms of schizophrenia with rare cases influenced by 22q11.2 deletions. This work was in collaboration with the INSPIRE early psychosis team at Stanford.
Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa
Duncan et al (2017) American Journal of Psychiatry
This flagship publication of the Psychiatric Genomics Consortium (PGC) Eating Disorders group (PGC-ED) identified the first genetic variant associated with anorexia nervosa and revealed shared biology between very low body weight (in anorexia) and high body weight (obesity). This was the most powerful genome-wide association study of anorexia to date and - through identification of metabolic factors sharing genetic influences with anorexia - encourages re-conceptualization of anorexia as a disorder with both psychiatric and metabolic etiology.
July 2017: TEACHING
Global Initiative for Neuropsychiatric Genetics Education in Research
Scholars from multiple African nations gathered in Boston in for the GINGER program, which is a "collaboration between the Harvard Chan School, the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, and multiple African universities and institutes.” Our lab contributed lectures for the event and it was exciting to meet these dynamic researchers.
May 2017: GRANT awarded
Quantifying individual genetic risk in diverse populations
This grant supports work that will quantify the performance of polygenic scores in diverse populations, test population genetics based hypotheses about predictive performance, and identify best practices in the application of polygenic risk scores to diverse populations. Dr. Benjamin Domingue is co-PI on the study, and collaborators are Dr. Johathan Pritchard, Dr. Booil Jo, and Hanyang Shen.
September 2017: VIDEO spotlight
American Journal of Psychiatry website
Dr. Daniel Pine, of the American Journal of Psychiatry highlights an article titled "Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa" by Laramie Duncan, Ph.D., and colleagues.
September 2017 AJP editor spotlight video on YouTube: (video)