401 Quarry Rd
Stanford, CA 94304
USA

Laramied@Stanford.edu

April 2019 PAPER

Duncan, Ostacher, & Ballon (2019)

Using an analytical approach and schizophrenia GWAS results, our new piece demonstrates, 'How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete'. Published in Neuropsychopharmacology (pdf), with coverage here.

January 2020 Paper

Shen et al. Neuropsychopharmacology

We report findings from the largest psychiatric GWAS in South America to date and provide summary statistics for depression, PTSD, and suicidal ideation/self-harm in this Peruvian sample.  Out now in NPP  (pdf, link) / Neuropsychopharmacology.  Congrats to Hanyang and thanks to awesome collaborators: Drs. Bizu Gelaye, Marta Rondon, Sixto Sanchez, and Hailiang Huang!

April 2019 PAPER

Duncan, Ostacher, & Ballon (2019)

Using an analytical approach and schizophrenia GWAS results, our new piece demonstrates, 'How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete'. Published in Neuropsychopharmacology (pdf), with coverage here.

November 2019 Grant

Benson Kung

Congrats to Benson Kung for being awarded an Undergraduate Research Grant from Stanford for his work using Natural Language Processing (NLP) and machine learning to improve understanding of psychiatric disorder symptom trajectories.

April 2019 PAPER

Duncan, Ostacher, & Ballon (2019)

Using an analytical approach and schizophrenia GWAS results, our new piece demonstrates, 'How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete'. Published in Neuropsychopharmacology (pdf), with coverage here.

October 2019 PAPER  Cell

Peterson et al...Duncan (senior author) 

Published in Cell, this primer provides best practices for the analysis of genomic data from diverse populations.  This is the flagship paper of the Psychiatric Genomics Consortium (PGC) Cross-Population Special Interest Group (chairs Duncan & Huang), and it was made possible via collaborative efforts from multiple leading statistical genetics groups around the globe. 

April 2019 PAPER

Duncan, Ostacher, & Ballon (2019)

Using an analytical approach and schizophrenia GWAS results, our new piece demonstrates, 'How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete'. Published in Neuropsychopharmacology (pdf), with coverage here.

August 2019 Presentation

Alex Bhatt

Summer undergraduate research student Alex Bhatt presented at the poster session.  Congrats Alex!!

April 2019 PAPER

Duncan, Ostacher, & Ballon (2019)

Using an analytical approach and schizophrenia GWAS results, our new piece demonstrates, 'How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete'. Published in Neuropsychopharmacology (pdf), with coverage here.

July 2019 PAPER

Duncan et al. (2019)

Our recent work in Nature Communications (pdf) demonstrates that polygenic scoring studies have overwhelmingly included European ancestry populations.  Moreover, polygenic scores perform poorly in many populations as a result of the limited ancestral diversity in many medical genetics studies.  

April 2019 PAPER

Duncan, Ostacher, & Ballon (2019)

Using an analytical approach and schizophrenia GWAS results, our new piece demonstrates, 'How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete'. Published in Neuropsychopharmacology (pdf), with coverage here.

June 2019 Teaching award

Dr. Duncan

Dr. Duncan received an award for excellence in teaching from the Stanford Psychiatry Residents.

April 2019 PAPER

Duncan, Ostacher, & Ballon (2019)

Using an analytical approach and schizophrenia GWAS results, our new piece demonstrates, 'How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete'. Published in Neuropsychopharmacology (pdf), with coverage here.

April 2019 PAPER

Duncan, Ostacher, & Ballon (2019)

Using an analytical approach and schizophrenia GWAS results, our new piece demonstrates, 'How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete'. Published in Neuropsychopharmacology (pdf), with coverage here.

December 2018 PAPER

Duncan, Cooper, & Shen (2018)

For a concise review of what is known about PTSD genetics, see our lab's recent review, 'Robust Findings from 25 Years of PTSD Genetics Research' in Current Psychiatry Reports.  Scope Blog coverage here, and paper download here.

October 2018 PAPER

Kimerling, Allen, & Duncan (2018)

We are delighted to share this comprehensive overview of multi-level influences on PTSD risk, across sex and gender (lead author Dr. Rachel Kimerling).  See 'Chromosomes to Social Contexts: Sex and Gender Differences in PTSD' in Current Psychiatry Reports (link and pdf).

November 2018 GRANT

 

WHSDM seed grant awarded (PI Duncan)

Our work investigating the causes of differences in PTSD, between women and men, was awarded a seed grant from WHSDM at Stanford..  Building upon our previous work with the international Psychiatric Genomics Consortium's PTSD group, we will be testing hypotheses about differing genetic risk factors in women and men, which can ultimately be leveraged to improve the treatment and prevention of trauma-related disorders.

June 2018 PAPER

Brainstorm Consortium (2018) Science

Analysis of over 1 million individuals revealed that psychiatric and neurological disorders are relatively genetically distinct from one another.  This analysis also supports previous findings of shared genetic effects across psychiatric disorders like schizophrenia, depression, bipolar disorder, and PTSD.  Popular media coverage is available: Scientific AmericanThe Economist. and congrats especially to Verneri Antilla (lead author).

2018 PAPER

Duncan et al. (2018) Schizophrenia Bulletin

Genetic correlation analyses reveal relationships between schizophrenia and personality traits (openness to experience and neuroticism) and also suggest a novel underlying pathway involving citrate.  Intriguingly, this mechanism may link polygenic forms of schizophrenia (encompassing most cases) with rare instances caused by 22q11.2 deletions.  This work was in collaboration with the INSPIRE early psychosis team; paper download here

September 2017:    VIDEO spotlight

American Journal of Psychiatry website

Dr. Daniel Pine, of the American Journal of Psychiatry highlights an article titled "Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa" by Laramie Duncan, Ph.D., and colleagues.

September 2017 AJP editor spotlight video on YouTube:  (video)

July 2017:     TEACHING

Global Initiative for Neuropsychiatric Genetics Education in Research (GINGER)

Scholars from multiple African nations gathered in Boston in for the GINGER program, which is a collaboration between the Harvard Chan School, the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, and multiple African universities and institutes.  Our lab contributed lectures for the event and it was exciting to meet these talented researchers.