Selected Publications (65 total):

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Duncan LE, Li T, Salem M, Li Will, Mortazavi L, Senturk H, Shargh N, Vesuna S, Shen H, Yoon J, Wang G, Ballon J, Tan L, Pruett BS, Knutson B, Deisseroth K. Giardino WJ. (2025) Mapping the Cellular Etiology of Schizophrenia and Diverse Brain Phenotypes Nature Neuroscience, 28, 248-258.

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Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JR, Daskalakis NP, Duncan LE… Koenen KC (2024) Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nature Genetics 56(5), 792-808.

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Zhou B, Arthur JG, ... Urban A (2024) Detection and analysis of complex structural variation in human genomes across populations and in brains of donors with psychiatric disorders Cell 187 (23), 6687-6706. e25

 

Tan L, Shi J, Moghadami S, Wright CP, Parasar B, Seo Y, Vallejo K, Cobos I, Duncan L, Chen R, & Deisseroth K (2023) Cerebellar Granule Cells Develop Non-neuronal 3D Genome Architecture over the Lifespan. Science

 

Duncan L & Deisseroth K (2023) Are novel treatments for brain disorders hiding in plain sight? Neuropsychopharmacology doi:10.1038/s41386-023-01636-x.

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Guo MG, Reynolds DL, Ang CE, Liu Y, Zhao Y, Donohue LK, Siprashvili Z, Yang X, Yoo Y, Mondal S, Hong A, Kain J, Meservey L, Fabo T, Elfaki I, Kellman LN, Abell NS, Pershad Y, Bayat V, Paam Etminani P, Holodniy M, Geschwind DH, Montgomery SB, Duncan LE, Urban AE, Altman RB, Wernig M, Khavari KA. (2023) Integrative analyses highlight functional regulatory variants associated with neuropsychiatric diseases. Nature Genetics 55, 1876-1891.

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Duncan L, Shen H, Schulmann A, Li T, Kolachana B, Mandal A, Feng N, Auluck P, & Marenco S (2023) Polygenic Risk Scores for Psychiatric Disorders in a Diverse Postmortem Brain Tissue Cohort. Neuropsychopharmacology Apr;48(5):764-772. doi: 10.1038/s41386-022-01524-w.

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Cusack SE, Maihofer AX, Bustamante D, The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group, Amstadter AB, Duncan LE (2024) Genetic influences on testosterone and PTSD Journal of Psychiatric Research 174, 8–11.

Duncan LE, Shen H, Schulmann A, Li T, Kolachana B, Mandal A, Feng N, Auluck P, Marenco S (2023). Polygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort. Neuropsychopharmacology 48(5), 764–772.

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Meijsen J, Shen H, Vemuri M, Rasgon NL, Koenen KC, Duncan LE (2021) Shared Genetic Influences on Depression and Menopause-Related Symptoms. Psychological Medicine Apr;53(6):2241-2251. doi: 10.1017/S0033291721004037.

 

Zhu X …  Duncan LE  … Urban A (2021) Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia. Nature Neuroscience 24(2), 186-196.

 

Martin J … middle author Duncan LE … Stahl E (2021) Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits.  Biological Psychiatry 89(12), 1127-1137.

 

Shen H, Gelaye B, Huang H, Rondon M, Sanchez S, Duncan LE (2020) Polygenic Prediction and GWAS of Depression, PTSD, and Suicidal Ideation in a Peruvian Cohort. Neuropsychopharmacology, 1-8. https://doi.org/10.1038/s41386-020-0603-5 

 

Peterson RE, … multiple authors, Duncan LE (2019) Genome-wide association in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations. Cell, 179 (3): 589-603.  [pdf]

 

Duncan LE, Shen H, Gelaye B, Meijsen J, Ressler K, Feldman M, Peterson R, Domingue B (2019) Analysis of Polygenic Score Usage and Performance in Diverse Human Populations. Nature Communications, 10, 1-9.  [pdf]

 

Duncan LE, Ostacher M, & Ballon J (2019) How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete. Neuropsychopharmacology 44, 1518-1523. [pdf] 

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Sperling EA, Tecklenburg S, & Duncan LE (2019). Statistical inference and reproducibility in geobiology. Geobiology, 17(3), 261–271. https://doi.org/10.1111/gbi.12333.  [pdf]

 

Duncan LE, Ratanatharathorn A, Aiello AE, Almli LM, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bierut LJ, Bisson J, Bradley B, Chen C-Y, Dalvie S, Farrer LA, Galea S, Garrett ME, Gelernter JE, Guffanti G, Hauser MA, Johnson EO, Kessler RC, Kimbrel NA, King A, Koen N, Kranzler HR, Logue MW, Maihofer AX, Martin AR, Miller MW, Morey RA, Nugent NR, Rice JP, Ripke S, Roberts AL, Saccone NL, Smoller JW, Stein DJ, Stein MB, Sumner JA, Uddin M, Ursano RJ, Wildman DE, Yehuda R, Zhao H, Daly MJ, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC. (2018) Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. Molecular Psychiatry, 23(3):666-673.  [pdf]

 

Duncan LE, Shen H, Ballon J, Hardy K, Noordsy D, Levinson D. (2018) Genetic Correlation Profile of Schizophrenia Mirrors Epidemiological Results and Suggests Link Between Polygenic and Rare Variant (22q11.2) Cases of Schizophrenia. Schizophrenia Bulletin 44(6):1350-1361.  [pdf]

 

Duncan LE, Cooper B, Shen H. (2018) Robust Findings From 25 Years of PTSD Genetics Research. Current Psychiatry Reports, 20(12), 115.  [pdf]

 

Kimerling R, Allen MC, & Duncan LE (2018) Chromosomes to Social Contexts: Sex and Gender Differences in PTSD. Current Psychiatry Reports, 20(12), 114.  [pdf]

 

Anttila V, Bulik-Sullivan B, Finucane HK, Walters R, Bras J, Duncan LE, et al (2018). Analysis of Shared Heritability in Common Disorders of the Brain. Science Jun 22;360(6395).  [pdf]

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